flavor of the month meaning

Flavor of the month What's the meaning of the phrase 'Flavor of the month'? Something that is prominent in the public eye for a short time then fades out of interest. Originally a term of approval for something that was up to the minute and desirable.

Flavor of the month

It has been used ironically from the late 20th century to pass disdainful comment on things which pass out of fashion quickly; for example, the "" one hit wonders "" of the music business. What's the origin of the phrase 'Flavor of the month'? This website is based in England and so we prefer UK spellings. In this case ""flavor"" is more appropriate than the UK ""flavour"", for reasons that will become apparent. The phrase dates back to 1930s USA and originated in the advertising slogans of ice-cream companies there. It isn't absolutely clear which company first used this in their campaigns. Search as I may for references to this phrase I can't find any that pre-date 1936. The earliest I've found is an advert in The Mansfield News Journal, June 1936:""If you haven't tried Sealtest Fresh Strawberry Ice Cream, made by Telling's, you're missing a real treat. It's the flavor-of-the month for June, selected by the Sealtest Jury. ""The idea must have taken off quite quickly. There are several other US ice-cream companies that began using the term in the 1940s. By 1946 it had become well enough established for a trade association to have taken an interest in it. The September 1946 issue of the Ice Cream Review records:""The Illinois Association of Ice Cream Manufacturers has set up a committee which will give serious study to a suggested flavor and flavor-of-the-month program for 1947. ""That 'program' and 'serious study' suggests that this phrase was well-entrenched by 1946. See other phrases that were coined in the USA. "


benefits of the master cleanse lemonade diet

The Master Cleanse (also called The Lemonade Diet) is a modified juice fast that's often used for rapid weight loss. It's a liquid diet that provides a healthy amount of calories and nutrients specifically suited for cleansing, all while resting the digestive system and allowing the body to heal naturally.

How To Master Cleanse and Lemonade Diet to Detox and Lose Weight âF.A.S.T.â

How To Master Cleanse and Lemonade Diet to Detox and Lose Weight “F. A. S. T.”

The Master Cleanse has been tested and approved since 1940 by millions of people all around the world and is constantly reported as the most successful diet of its type. As the originator of this superior diet once stated: “I humbly and yet proudly offer it to you, confidant that you will receive vigorous good health from its use”Stanley Burroughs –Author of the book “ The Master Cleanser “– continues to state:“This diet will prove that no one needs to live with their diseases. A lifetime of freedom from disease can become a reality. The Lemonade diet has successfully and consistently demonstrated its eliminating and building ability.”The Master Cleanse is such a simple program to teach in 100 words or less: First, squeeze Fresh Lemon Juice. Then add Rich Maple Syrup, and Cayenne Pepper into Pure Water. Drink a minimum of six to 12 glasses throughout the day whenever one is hungry ( For the Lemonade diet recipe with exact measurements, scroll down this page)Take a laxative before bed.instead of the morning laxative, you can do the Salt Water Flush. Every day of The Master Cleanse that you overcome the psychological need to eat, you feel a growing sense of control that motivates you to complete the process. The Master Cleanse is by far my favorite of the Detox Diet Recipes. There are Three Secrets to The Master Cleanse: Ease-In and Ease-Out : The 3 days before and after The Lemonade Diet that slowly removes or re-introduces complex, processed (C. R. A. P.) foods from your diet. The Lemonade Diet: 10 Days to Lose Weight Fast, and Feel Great At Last Every Day Detox: Every day a Natural Detox Method must be engaged to eliminate Waste such as Detox Tea and The Salt Water Flush Each of these will be explained in detail, and it is very important to follow these directions carefully. If you read closely you shouldn't have many questions, but of course there is always more to know, so check out the comments. Most of your other questions will be answered there. Since I get so many of the same questions, I will be making a FAQ or Frequently Asked Questions page very soon. The Complete Master Cleanse by Tom Woloshyn There are often questions regarding the precise ingredients for the Master Cleanser Recipe, as they can vary somewhat, depending on your experience and requirements. Be sure to choose which is right for you and learn how to best be prepared for The Master Cleanser Side Effects. The best way to prepare for the Master Cleanse is to get educated about all the ingredients and their purpose as well as the Cleaning process that takes place. Reading the recommended books written on the Master Cleanse topic is a very good investment of your time and energy. Everyone goes through different, very individual healing process and this may prepare you for it's ups and downs. Ease-In – Starting The Master Cleanse The Ease-In step of The Master Cleanse (Pre-Diet Routine) is not as important as the Ease-Out (Post-Diet Routine). In fact, you could skip the Ease-In completely and begin directly with The Lemonade Diet at anytime. In my experience, however, beginning The Lemonade Diet with the Ease-In routine not only prepares your stomach for less food, but your mind as well. The purpose of Easing-into the Cleanse I find by doing the Ease-In, the first two days of the Diet are not as shocking, and the impulse to eat is therefore more manageable. It allows you to prepare your body for the dramatic change in diet as you cleanse but it will also prepare you for the next 10 days : mentally and emotionally, which can prevent you from ending the Master Cleanse too soon. Use the 3 days of the Ease-In to gather your ingredients for the Master Cleanser Recipe. The Lemonade Diet Whether you begin The Lemonade Diet immediately or Ease-In, the process of the Lemonade Diet is the same. You will however, need to make two decisions to suit your personal preferences and/or your daily work and family routines. The first Master Cleanse Variation revolves around timing your daily flush. Perhaps equally important as Ending The Master Cleanse is the Daily Detox Bowel Movement. It is crucial to flush out the toxins your body is eliminating, and since you are not consuming digestible food (fiber) to create a bowel movement, you will have to make that happen. Lemonade Diet Ingredients Awake, and prepare your Lemonade – this is your nourishment and energy source for the day. Soon after arising you will prepare your daily intake of Fresh Lemon Juice, Rich Maple Syrup, Cayenne Pepper and Pure Water. Lemonade Diet Recipe Mix each of the following lemonade diet ingredients into a large glass:2 Tablespoons Fresh Lemon Juice2 Tablespoons Rich Maple Syrup1/10 Teaspoon of Cayenne Pepper Powder – or to taste (as much as you can stand)8 ounces (250 milliliters of Pure Water)Little tip: Roll each lemon firmly between your palm and the counter. Put sufficient downward pressure as you rock the lemon back and forth under your hand. You are softening the lemon to make the extraction of juice more efficient. See this post for detailed tips on The Lemonade Diet. How much Lemonade should you drink during the day? You will drink between 6 and 12 glasses of Lemonade each day (some people drink as much as 26 glasses per day). The more you can drink, the better. I try to drink at least 8 glasses each day. This will depend on how big or small you currently are (caloric needs), your tolerance to physical and psychological urges to eat, and your desire to to lose weight. Every Day Detox This is why I call this process “The Daily Detox Bowel Movement”. It is this process that cleanses your body of the waste, and toxins. There are two accepted methods to produce Daily Detox Bowel Movements: Salt Water Flush Nightly Detox Tea Prior to your first day on The Lemonade Diet you should have taken your Nightly Laxative. On your first full day you do not need to do the SWF so you can start drinking your Lemonade immediately upon waking. How much weight will I lose during the Master Cleanse? Master Cleanse Weight Loss results vary according to your pre-cleanse weight, and can be managed, to a degree, by how much lemonade you drink. Obviously you can Drink more, for less weight loss, and drink less to lose more weight. It is not a wise choice to drink less than 6 glasses in an effort to lose “extra” weight. Weight loss (if any), should occur naturally. It is wise to drink whenever you're hungry, or when you feel a lack of energy (commonly felt as a weakness or mild shakiness), which is quickly corrected by drinking a glass of Fresh Lemonade. 12 glasses per day should be your starting point from which you will make adjustments. How long should I do the Cleanse for? Tom Woloshyn claims the longest he has heard of is 372 days straight with the second longest being 256. Some people do “Cleanse Stacks” where they will do 10 days followed by some regular eating and quickly going back on for another 10 days as many as 5 times. My suggestion is that 2 weeks is more than enough. There are reasons for Long Term Master Cleansing such as Disease Cleansing, but that topic is far outside of the scope of this article. Ease-Out – Stopping The Master Cleanse The Ease-out process of The Master Cleanse is the exact same as the Ease-In, but in reverse. This is also another reason I choose to do the Ease-In – it prepares me for the Ease-Out. You will be tempted to fast-track this process, but DON'T. Why is the Ease – out so important? Consider this step as ESSENTIAL. You can become nauseated if you start to eat too soon. Please don't underestimate the importance of this process. On the other hand, don't be scared of it either. You do risk some serious constipation or some of the worse Complications of The Master Cleanse – but if you eat something too soon, you will likely be okay in the long run. If you are unsure at any time – consult a doctor. My words here are opinion only, and should always be considered informational not medical advice. Here is a quote from Tom Woloshyn's book The Complete Master Cleanse On the Easing – out : ” The important transition period of moving from lemonade to food will prepare your digestive system for more and more complex foods so that it does not become overwhelmed. Just as you wouldn't try running a marathon after being a couch potato for three years, you wouldn't brake a cleanse by launching into full-feasting mode. You want your digestive system to get well-deserved brake so that your body can start back on the right track. ”Post Cleanse – Adopt a Healthy Lifestyle – After The Master Cleanse When you are done The Master Cleanse, the next and maybe most important step is to begin to Eat Wisely. This sounds so simple, yet so many people go right back to eating emotionally to sooth their daily worries. Choose to Eat Wisely and you will not put the weight back on. If you go back to Eating Poorly, you will gain back all the weight you just lost – and maybe more!Make sure to start taking Probiotics after you finished the Cleanse. It is very important to replenish the good bacteria in your body that has been flushed out during the Cleansing process. The word “probiotic” means “for life.” Probiotics are good bacteria that provides many health benefits and are essential for many vital body functions, including healthy digestion. Now You KNOW How To Master Cleanse So now what? What's Next? Pick Your Start Date Get Your Master Cleanse Kit Get Your After Master Cleanse Kit Join The Group Cleanse and Social Channels for Support and Fun!Lose Weight & Feel Great Pick Your Start Date In our experience, Friday's are great days for starting the Ease-In, leaving the following Monday for you to begin your Lemonade Diet. Strategically this makes your starting weekend a hybrid of cleanse and food. This also leaves the Ease-Out to fall prior to the end of the second week, and ultimately only 1 full weekend while on the Lemonade Diet. This helps substantially with people's work and social schedules. Finally, choosing your seasonal selection is also important. Look at your calendar and and notice major events like National Holidays, and personal events like weddings, graduations, etc. Find the first opportunity that you have 2 weeks off following one of these events. You can then really dig in and enjoy your last indulgences and get ready for a fresh start free from any of the pitfalls and temptations that these events are certain to cause. Get Your Master Cleanse Kit There are 3 parts to your Master Cleanse Kit. Part 2, Lemons, of course are perishable. So you should try to get those locally, although Amazon.com will deliver Fresh Lemons directly to your door, along with the readily available non-perishable ingredients making up part of The Master Cleanse Kit including Maple Syrup, Cayenne Pepper, Sea Salt, and Laxative Teas or Laxative Pills. Part 3 of your Master Cleanse Kit might include the equipment or accessories you might need like a hand juicer, tablespoon measures and water bottles. All of these items can be found on Amazon.com, where we suggest you get your kit, saving you the effort of sourcing all these items independently. Get Your After Master Cleanse Kit It's so important to over-look what to do “After” the Master Cleanse. After-all, just start eating again right? Naturally, following the Ease-In, if done right and transitioned into Eating Healthy, we'll rebuild naturally over time. During The Master Cleanse, we've strategically reduced intake of certain nutrients, like Protein, Fats, and a select group of Vitamins where sidelined for a few days. Now it's time to rebuild. We have to rebuild our internal flora, using Probiotics. We should supplement our Vitamins and Nutrients with a Plant Based, and natural Multivitamin, and finally we should rebuild our Amino Acids and Proteins using an all natural Whey Protein. Join the Group Cleanse for Support and Fun!Now that you're committed, why not join our Group Cleanse. Hundreds of people do one of 4 scheduled Group Cleanses after the major holidays, but there are also Independent Group Cleanse with dozens of participants on any given day of the year. You'll be amazed how helpful, and FUN, having someone to share with, learn from, and lean on during the challenge of becoming a Master Cleanser. Not to mention you can flex your Social Networking, Blogging and Publishing skills that might even land you your very own blog just like The Master Cleanse.org. Check out our Group Cleanse page for details. Join The Conversation on our Social Channels The Master Cleanse.org is everywhere you want to connect with us. We creating content, supporting our community, and engaging in conversations on all the major networks. Click through and subscribe to us on each to stay up to date with all the great news, and insight on Cleansing, Detox, Weight Loss, Diets, Healthy Eating, Holistic Healing, Personal Health Management (Self Care), and Personal Development. Lose Weight & Feel Great – Like Dr. Wayne Dyer Did Yes The Master Cleanse is about Cleanse and Detox, but many of you are for the Weight Loss. Well, great news! As a reduction diet, The Master Cleanse is beyond compare. Be prepared to lose up to 2 lbs per day as fat melts away. Please note, that this is not typical, and results definitely vary. You'll only lose weight if your body feels you need to. Some people, especially those underweight or malnourished can sometimes put on weight. Most people however, carrying extra weight in fat, will see dramatic, fast, and natural weight loss. Last but not least, the Cleanse and Detox is a Whole Body experience. You'll not only feel great about how you look, but you'll be more aware, proud, and empowered with your ability to be confident, committed in your new healthy lifestyle. Not to mention the famous “Cleansers” High most notably touted by Dr. Wayne Dyer, who proclaims: I feel great and taken weight off around my middle. It's just kinda disappeared. I have lost 14 or 15 pounds I have more energy. I am doing yoga again. I am back walking. I was having real issues with my back. Joint pains and things like that seem to have all gone. I have a new kind of clarity as well. Happy Cleansing everyone and Thank you for visiting our website! We hope to see you here soon again. If You're Ready… Now you need to…


the function of the olfactory nerve concerns

her!Function of the Olfactory Nerve The olfactory nerve is responsible for your sense of smell and partially responsible for your sense of taste. It is also known as cranial nerve 1 because it is the shortest of the cranial nerves and one of only two nerves (the other is the optic nerve) that bypass the brain stem and connect directly to your brain.

Olfactory Nerve: Function, Disorders & Regeneration

Your next lesson will play in 10 seconds Add to Timeline Autoplay 6.7K views Create an account to start this course today Try it free for 5 days!Create An Account Recommended Lessons and Courses for You Related Lessons Related Courses Trochlear Nerve: Function, Damage & Palsy Hypoglossal Nerve: Function, Palsy & Damage Glossopharyngeal Nerve: Function, Damage & Test The Sense of Smell: Olfactory Bulb and the Nose Lesson Transcript Instructor: Betsy Chesnutt Betsy teaches college physics, biology, and engineering and has a Ph. D. in Biomedical Engineerin

g Your olfactory nerve is responsible for your sense of smell and plays a big part in your sense of taste, too. Learn about how it works, disorders th

at affect it, and how it can regenerate. Can You Smell That? Close your eyes and imagine that you are walking through a garden of roses. How do you know there are roses around you if your eyes are closed? You can smell them, right? The smell of a rose is easily identifiable to most people. In fact, you have the ability to detect millions of different odors, from the pleasant smell of a rose garden to the harsh smell of a burning building. Without a properly functioning olfactory nerve, you wouldn't be able to smell any of these things. Your olfactory nerve is also very important in giving you a sense of taste, so if it is not functioning, then you wouldn't be able to taste much eit

The job of your olfactory nerve is to detect chemicals floating around in the air and transmit information about them to your brain, where you interpret this as a certain smell. Let's look at exactly what happens when you smell something, like a rose. First, small droplets of chemicals that are released by the rose enter your mouth and nose when you breathe. These chemicals dissolve into the mucous layer that lines your nasal cavity. High up inside your nose, about 7 cm above and behind your nostrils, is a region of the nasal cavity known as the olfactory epithelium. The cells there, called olfactory epithelial cells, are very specialized. On the side facing your nasal cavity (and so exposed to the smell-inducing chemicals), they are covered with tiny hairs called cilia, and on the other side, they are connected to an axon, which is the main body of a nerve cell. The cilia react to specific chemicals and send electrical signals through the axons of the olfactory nerve to your brain. Each axon passes through small holes in your skull in an area known as the cribriform plate. Just below your brain, they all pass into the olfactory bulb, where the signals from each axon come together and are sent on to the brain via the olfactory tract. Once these electrical signals get to your brain, neurons there interpret the specific pattern of impulses as a specific smell. Some of the parts of your brain responsible for smell are also responsible for memory and emotions, which is why a certain smell can trigger a specific memory or emotion every time you encounter it. Disorders of the Olfactory Nerve Damage to the olfactory nerve can result in three different disorders. The first, anosmia is an inability to smell at all. Some people with olfactory nerve damage develop anosmia, but some simply have a reduced ability to smell. This is called hyposmia. Finally, olfactory nerve disorders can cause people to develop dysosmia, where smells are mixed up so that a pleasant aroma like that of a rose might smell bad, like rotting garbage. Most of the time, anosmia and hyposmia are temporary and are caused by inflammation in the nasal cavity which prevents chemicals from reaching the olfactory epithelium. This is what happens when you have a cold or sinus infection. Sometimes, however, these conditions can become permanent. This can happen if certain viruses or toxins damage the epithelial cells of the olfactory system, or if they are damaged by trauma. This often happens when the cribriform plate is broken, severing the axons of the olfactory nerve. Even if the cribriform plate is not broken, a blow to the head or face can damage these delicate cells and result in a partial or total loss of smell. To unlock this lesson you must be a Study.com Member. Create your account Register for a free trial Are you a student or a teacher? I am a student I am a teacher


what is .img format

n.4. The IMG file format, also known as GEM IMG, is an image file format used to store bitmap digital images on Graphical Environment Manager.5. A graphics image format used in various ways by many different graphics software packages. IMG files are used for:

What is IMG file format?

"What is IMG file format? The IMG file format is one of the following files:1. A CD or DVD image file, essentially equivalent to an ISO file. On such a file, simply changing the extension from IMG to ISO can make it usable as the latter by most programs.2. An archive format used for creating a disk image of floppy disks and HDDs. This allows for digital storage, transmission, and replication of floppy disks and HDDs. Files created using this format typically use the "". IMG"" file extension.3. A file in the Macintosh Disk Image format used by Aladdin Systems (now Allume Systems) Shrink Wrap and Apple Disk Copy for Mac OS although they share the same file extensio

● Digital storage, transmission, and replication of floppy disks.● Mounting virtual floppy disk volumes. Win ISO can edit the . IMG disc images. Want to know how to convert . ISO to . IMG? Go Win ISO tutorial to get more guides or click here directly. Related Articles BIN Image File NRG Image File Make bootable ISOCreate ISOWin ISO Standard 6: Buy Win ISO Standard 6 $19.95 $29.95Free Download Win ISO Standard 6 "


what are inotropic meds

at. Plush Studios/Riser/ Getty Images An inotropic drug is a medicine that alters the force or strength of the heart 's muscular contractions (heartbeats). There are two different types of inotropic drugs: negative and positive. Negative inotropic drugs make the heart beat less strongly, and positive inotropic drugs make the heart beat more strongly. Both kinds are used in the management of various conditions that affect the function of the heart.

Inotropic Drugs: What You Need to Know

NEXTInotropic drugs alter the strength of your heartbe

One of the most important factors affecting the strength of the heart's muscular contractions is the level of calcium in the fluid inside the heart's muscle cells. Calcium is one of the most common electrolytes in the human body. Other common electrolytes are sodium, potassium, chloride and magnesium. We need the right balance of these electrolytes for proper functioning of the heart, nerves, muscles and kidneys. Electrolytes are minerals that come from the foods we eat and fluids we drink. They're found in the fluids throughout the body -- not only in the blood and urine, but also inside the body's cells and in the space surrounding the cells. Like their name suggests, electrolytes have an electrical charge, and they conduct electrical impulses ( electricity ). Electrical impulses generate muscle contractions. The level of each of the electrolytes must be kept within a narrow range in order for the body to function properly. In particular, it's important to maintain precise differences between the levels of electrolytes in the fluids inside the cells and outside the cells. It's these differences that allow our cells (especially nerve, heart and muscle cells) to maintain electrical voltages across their cell membranes, generate electrical impulses and produce muscle contractions. Calcium plays an important role in the process of heart muscle contraction. In general, calcium levels are increased by positive inotropic drugs and decreased by negative inotropic drugs. But different types of inotropic drugs change calcium levels in different ways. Next, we'll learn about the different kinds of inotropic drugs.


what is nabumetone used to treat

TOPNabumetone is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and help relieve symptoms of arthritis ( osteoarthritis and rheumatoid arthritis ), such as inflammation, swelling, stiffness, and joint pain. This medicine does not cure arthritis and will help you only as long as you continue to take it .

What is Nabumetone?

What is Nabumetone? Nabumetone discount prices start at just $17.42!Therapeutic Classifications Analgesic Pharmacologic Classifications NSAIDQUICK LINKSBlackbox Warning Overview Proper Use Dosing Missed Dose Use & Storage Before Using Allergies Pediatric Geriatric Pregnancy Breast Feeding Drug Interactions Other Interactions Other Medical Problems Precautions Chemical Classifications Advertisement Blackbox Warning TOPOral route (Tablet)NSAIDs cause an increased risk of serious or fatal cardiovascular thrombotic events, myocardial infarction, and stroke.

Nabumetone is contraindicated in the setting of CABG surgery. NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms.

Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events . Save up to 72% on Nabumetone Find big savings at pharmacies near you with Good Rx discount coupons Average Retail Price:$62.32Lowest Good Rx Price$17.42View All Prices Overview

This medicine is available only with your doctor's prescription . Proper Use TOPFor safe and effective use of this medicine, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of this medicine may increase the chance of unwanted effects, especially in elderly patients . When used for severe or continuing arthritis, this medicine must be taken regularly as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine. You may take this medicine with or without food . Dosing TOPThe dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For osteoarthritis and rheumatoid arthritis: Adults—At first, 1000 milligrams (mg) once a day, in the morning or evening, or 500 mg twice a day, in the morning and evening. Your doctor may increase the dose, if necessary, up to a total of 2000 mg a day. Children—Use and dose must be determined by your doctor . Missed Dose TOPIf you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Use & Storage TOPStore the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Ask your healthcare professional how you should dispose of any medicine you do not use. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Before Using TOPIn deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies TOPTell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric TOPAppropriate studies have not been performed on the relationship of age to the effects of nabumetone in the pediatric population. Safety and efficacy have not been established . Geriatric TOPAppropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of nabumetone in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution in patients receiving nabumetone . Pregnancy TOPPregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding TOPThere are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Drug Interactions TOPAlthough certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Ketorolac Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abciximab Aceclofenac Acemetacin Acenocoumarol Amiloride Amineptine Amitriptyline Amitriptylinoxide Amoxapine Amtolmetin Guacil Anagrelide Apixaban Ardeparin Argatroban Aspirin Balsalazide Bemiparin Bendroflumethiazide Benzthiazide Betamethasone Betrixaban Bismuth Subsalicylate Bivalirudin Bromfenac Budesonide Bufexamac Bumetanide Cangrelor Celecoxib Certoparin Chlorothiazide Chlorthalidone Choline Magnesium Trisalicylate Choline Salicylate Cilostazol Citalopram Clomipramine Clonixin Clopamide Clopidogrel Cortisone Cyclopenthiazide Cyclosporine Dabigatran Etexilate Dalteparin Danaparoid Deflazacort Desipramine Desirudin Desmopressin Desvenlafaxine Dexamethasone Dexibuprofen Dexketoprofen Diazoxide Dibenzepin Diclofenac Diflunisal Digoxin Dipyridamole Dipyrone Dothiepin Doxepin Droxicam Duloxetine Edoxaban Enoxaparin Eplerenone Epoprostenol Eptifibatide Escitalopram Ethacrynic Acid Etodolac Etofenamate Etoricoxib Felbinac Fenoprofen Fepradinol Feprazone Feverfew Floctafenine Flufenamic Acid Fluocortolone Fluoxetine Flurbiprofen Fluvoxamine Fondaparinux Furosemide Ginkgo Gossypol Heparin Hydrochlorothiazide Hydrocortisone Hydroflumethiazide Ibuprofen Iloprost Imipramine Indapamide Indomethacin Ketoprofen Lepirudin Levomilnacipran Lithium Lofepramine Lornoxicam Loxoprofen Lumiracoxib Magnesium Salicylate Meadowsweet Meclofenamate Mefenamic Acid Melitracen Meloxicam Mesalamine Methotrexate Methyclothiazide Methylprednisolone Metolazone Milnacipran Morniflumate Nabumetone Nadroparin Naproxen Nefazodone Nepafenac Niflumic Acid Nimesulide Nimesulide Beta Cyclodextrin Nortriptyline Olsalazine Opipramol Oxaprozin Oxyphenbutazone Paramethasone Parecoxib Parnaparin Paroxetine Pemetrexed Pentosan Polysulfate Sodium Pentoxifylline Phenindione Phenprocoumon Phenylbutazone Phenyl Salicylate Piketoprofen Piroxicam Pixantrone Polythiazide Pralatrexate Prasugrel Prednisolone Prednisone Proglumetacin Propyphenazone Proquazone Protein CProtriptyline Reboxetine Reviparin Rivaroxaban Rofecoxib Salicylamide Salicylic Acid Salsalate Sertraline Sibutramine Sodium Salicylate Spironolactone Sulfasalazine Sulindac Tacrolimus Tenoxicam Tianeptine Tiaprofenic Acid Ticagrelor Ticlopidine Tinzaparin Tirofiban Tolfenamic Acid Tolmetin Torsemide Treprostinil Triamterene Trichlormethiazide Trimipramine Trolamine Salicylate Valdecoxib Venlafaxine Vilazodone Vorapaxar Vortioxetine Warfarin Xipamide Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acebutolol Alacepril Atenolol Azilsartan Azilsartan Medoxomil Benazepril Betaxolol Bisoprolol Candesartan Captopril Carteolol Carvedilol Celiprolol Cilazapril Delapril Dicumarol Enalapril Enalaprilat Eprosartan Esmolol Fosinopril Imidapril Irbesartan Labetalol Levobunolol Lisinopril Losartan Metipranolol Metoprolol Moexipril Nadolol Nebivolol Olmesartan Oxprenolol Penbutolol Pentopril Perindopril Pindolol Practolol Propranolol Quinapril Ramipril Sotalol Spirapril Telmisartan Temocapril Timolol Trandolapril Valsartan Zofenopril Other Interactions TOPCertain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Tobacco Other Medical Problems TOPThe presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Anemia or Asthma or Bleeding problems or Blood clots or Edema (fluid retention or body swelling) or Heart attack, history of or Heart disease (e.g., congestive heart failure) or High blood pressure or Kidney disease or Liver disease (e.g., hepatitis) or Stomach or intestinal ulcers or bleeding or Stroke, history of—Use with caution. This medicine may make these conditions worse . Aspirin sensitivity, history of—This medicine should NOT be used in patients with this condition . Heart surgery (e.g., coronary artery bypass graft [CABG] surgery)—This medicine should NOT be used to relieve pain right before or after the surgery . Precautions TOPIt is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects . This medicine may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk . This medicine may cause bleeding in your stomach or intestines. These problems can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years old, if you are in poor health, or if you are using certain other medicines (a steroid or a blood thinner) . Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you have any of the following symptoms while taking this medicine: blistering, peeling, loosening of skin, chills, cough, diarrhea, fever, itching, joint or muscle pain, red skin lesions, sore throat, sores, ulcers, or white spots in mouth or on lips, or unusual tiredness or weakness . Possible warning signs of some serious side effects that can occur during treatment with this medicine may include swelling of the face, fingers, feet, and/or lower legs; severe stomach pain, black, tarry stools, and/or vomiting of blood or material that looks like coffee grounds; unusual weight gain; yellow skin or eyes; decreased urination; unusual bleeding or bruising; and/or skin rash. Also, signs of serious heart problems could occur such as chest pain, tightness in chest, fast or irregular heartbeat, unusual flushing or warmth of skin, weakness, or slurring of speech. Stop taking this medicine and check with your doctor immediately if you notice any of these warning signs . This medicine may also cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur more often in patients who are allergic to aspirin or to any of the nonsteroidal anti-inflammatory drugs. Anaphylaxis requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in color of the skin of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swellings of the eyelids or around the eyes. If these effects occur, get emergency help at once . Using this medicine while you are pregnant can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away . This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds . Before having any kind of surgery or medical tests, tell your doctor that you are taking this medicine. It may be necessary for you to stop treatment for a while, or to change to a different nonsteroidal anti-inflammatory drug before your procedure . Chemical Classifications TOPAcetic Acid (class)Don't miss out on savings!x The best way to save on your prescriptions delivered to your inbox. Subscribe now Good Rx respects your privacy and we do not sell your personal information. By subscribing to emails, you agree to our terms of use and privacy policy.


what is islet transplantation

Islet transplantation is the transplantation of isolated islets from a donor pancreas into another person. It is an experimental treatment for type 1 diabetes mellitus. Once transplanted, the islets begin to produce insulin, actively regulating the level of glucose in the blood.

Islet cell transplantation

"From Wikipedia, the free encyclopedianavigation search Islet cell transplantation Microscopic image of an islet of Langerhans (lighter area) surrounded by exocrine pancreas tissue (darker staining). Me SH D016381 [ edit on Wikidata]

Islets are usually infused into the patient's liver. [1] If the cells are not from a genetically identical donor the patient's body will recognize them as foreign and the immune system will begin to attack them as with any transplant rejection. To prevent this immunosuppressant drugs are used. Recent studies have shown that islet transplantation has progressed to the point that 58% of the patients in one study were insulin independent one year after the operation. [2]In the period from 1999 to 2004, 471 patients with type 1 diabetes have received islet transplants at 43 institutions worldwide. [3]Contents1 History2 Goals3 Procedure4 Immunosuppression5 Limitations6 Future7 References8 External links History [ edit]The concept of islet transplantation is not new. [4] Investigators as early as the English surgeon Charles Pybus (1882–1975) attempted to graft pancreatic tissue to cure diabetes. Most, however, credit the recent era of islet transplantation research to Paul Lacy 's studies dating back more than three decades. In 1967, Lacy's group described a novel collagenase-based method (later modified by Dr. Camillo Ricordi, then working with Dr. Lacy) to isolate islets, paving the way for future in vitro and in vivo islet experiments. [5] Subsequent studies showed that transplanted islets could reverse diabetes in both rodents and non-human primates. [6] [7] In a summary of the 1977 Workshop on Pancreatic Islet Cell Transplantation in Diabetes, Lacy commented on the feasibility of “islet cell transplantation as a therapeutic approach [for] the possible prevention of the complications of diabetes in man”. [8] Improvements in isolation techniques and immunosuppressive regimens ushered in the first human islet transplantation clinical trials in the mid-1980s. The first successful trial of human islet allotransplantation resulting in long-term reversal of diabetes was performed at the University of Pittsburgh in 1990. [9] Yet despite continued procedural improvements, only about 10% of islet recipients in the late 1990s achieved euglycemia (normal blood glucose). In 2000, Dr. James Shapiro and colleagues published a report describing seven consecutive patients who achieved euglycemia following islet transplantation using a steroid-free protocol and large numbers of donor islets, since referred to as the Edmonton protocol. [10] This protocol has been adapted by islet transplant centers around the world and has greatly increased islet transplant success. Goals [ edit]The goal of islet transplantation is to infuse enough islets to control the blood glucose level removing the need for insulin injections. For an average-size person (70 kg), a typical transplant requires about one million islets, isolated from two donor pancreases. Because good control of blood glucose can slow or prevent the progression of complications associated with diabetes, such as nerve or eye damage, a successful transplant may reduce the risk of these complications. But a transplant recipient will need to take immunosuppressive drugs that stop the immune system from rejecting the transplanted islets. Procedure [ edit]The process of islet transplantation (illustration by Giovanni Maki). Researchers use a mixture of highly purified enzymes ( Collagenase) to isolate islets from the pancreas of a deceased donor. Collagenase solution is injected into the pancreatic duct which runs through the head, body and tail of the pancreas. Delivered this way, the enzyme solution causes distension of the pancreas, which is subsequently cut into small chunks and transferred into so-called Ricordi's chamber, where digestion takes place until the islets are liberated and removed from the solution. Isolated islets are then separated from the exocrine tissue and debris in a process called purification. During the transplant, a radiologist uses ultrasound and radiography to guide placement of a catheter through the upper abdomen and into the portal vein of the liver. The islets are then infused through the catheter into the liver. The patient will receive a local anesthetic. If a patient cannot tolerate local anesthesia, the surgeon may use general anesthesia and do the transplant through a small incision. Possible risks of the procedure include bleeding or blood clots. It takes time for the islets to attach to new blood vessels and begin releasing insulin. The doctor will order many tests to check blood glucose levels after the transplant, and insulin may be needed until control is achieved. Radiographic image of the portal vein and its branches in the transplant recipient before infusion of isolated islets. Post-transplant radiographic image of the recipient's portal tree. Immunosuppression [ edit]The Edmonton protocol uses a combination of immunosuppressive drugs, including daclizumab (Zenapax), sirolimus (Rapamune) and tacrolimus (Prograf). Daclizumab is given intravenously right after the transplant and then discontinued. Sirolimus and tacrolimus, the two main drugs that keep the immune system from destroying the transplanted islets, must be taken for life. Limitations [ edit]While significant progress has been made in the islet transplantation field, [11] many obstacles remain that currently preclude its widespread application. Two of the most important limitations are the currently inadequate means for preventing islet rejection, and the limited supply of islets for transplantation. Current immunosuppressive regimens are capable of preventing islet failure for months to years, but the agents used in these treatments are expensive and may increase the risk for specific malignancies and opportunistic infections. In addition, and somewhat ironically, the most commonly used agents (like calcineurin inhibitors and rapamycin) are also known to impair normal islet function and/or insulin action. Further, like all medications, the agents have other associated toxicities, with side effects such as oral ulcers, peripheral edema, anemia, weight loss, hypertension, hyperlipidemia, diarrhea and fatigue. [12] Perhaps of greatest concern to the patient and physician is the harmful effect of certain widely employed immunosuppressive agents on renal function. For the patient with diabetes, renal function is a crucial factor in determining long-term outcome, and calcineurin inhibitors ( tacrolimus and ciclosporin) are significantly nephrotoxic. Thus, while some patients with a pancreas transplant tolerate the immunosuppressive agents well, and for such patients diabetic nephropathy can gradually improve, in other patients the net effect (decreased risk due to the improved blood glucose control, increased risk from the immunosuppressive agents) may worsen kidney function. Indeed, Ojo et al. have published an analysis indicating that among patients receiving other-than-kidney allografts, 7%–21% end up with renal failure as a result of the transplant and/or subsequent immunosuppression. [13]Seen another way, patients with heart, liver, lung, or kidney failure have a dismal prognosis for survival, so the toxicity associated with immunosuppression is warranted (the benefits of graft survival outweigh the risks associated with the medications). But for the subset of patients with diabetes and preserved kidney function, even those with long-standing and difficult-to-control disease, the prognosis for survival is comparatively much better. In addition to the immunosuppressive toxicities, other risks are associated with the islet transplant procedure itself, including intra-abdominal hemorrhage following the transplant, and portal vein thrombosis. The fact that there is already a good alternative to islet transplantation (i.e. the modern intensive insulin regimen) forces us to regard any newer, riskier interventions with a critical eye. Like all transplantation therapies, islet transplantation is also handicapped by the limited donor pool. The numbers are striking; at least 1 million Americans have type 1 diabetes mellitus, and only a few thousand donor pancreata are available each year. To circumvent this organ shortage problem, researchers continue to look for ways to ""grow"" islets—or at least cells capable of physiologically regulated insulin secretion—in vitro, but currently only islets from cadaveric donors can be used to restore euglycemia. Further exacerbating the problem (and unlike kidney, liver, and heart transplants, where only one donor is needed for each recipient) most islet transplant patients require islets from two or more donors to achieve euglycemia. Lastly, the current methods for islet isolation need improvement, since only about half of attempted isolations produce transplant-ready islets. While islet transplantation research has made important progress and the success stories are encouraging, the long-term safety and efficacy of the procedure remain unclear. Other concerns relating to the field include questions about the impact of having insulin-producing foreign cells within the hepatic parenchyma, the long-term consequences of elevated portal pressures resulting from the islet infusion, and the fact that islet recipients can be sensitized against donor tissue types, making it more difficult to find a suitable donor should another life-saving transplant be required in the future. Also, very few islet transplant recipients have remained euglycemic without the use of any exogenous insulin beyond four years post-transplant. Thus, while most islet recipients achieve better glycemia control and suffer less serious hypoglycemia, islet transplantation continues to fall short of the definitive diabetes cure. Future [ edit]Just as early studies showed islet transplantation's promise, research must now overcome the hurdles revealed by the recent islet transplant experience. New immunomodulatory agents offer the greatest hope of revolutionizing the field. New drug regimens capable of inducing tolerance to the transplanted islets would allow recipients to maintain their grafts without general immunosuppression and its associated toxicities. While many targets are currently under investigation, none are ready for clinical use. Islet cells can also be encapsulated with a coating that protects them from the immune system, while still allowing the release of insulin. This is reported to be done in the ""bioreactor"" ßAir, a ""proprietary implantable bioartificial pancreas"" [14] developed by Israel -based medtech company Beta-O 2Technologies Ltd. The company was founded in 2004. The first implantation to a human patient was carried out in 2012 with a medical follow-up in Dresden's Technical University ( Germany) for 10 month, and ßAir's Phase I Safety/Efficacy Study ( clinical trial) started in 2014 at Uppsala University Hospital in Sweden. [15] Reportedly free from having to check blood glucose level and inject insulin, the ßAir-implanted patient will still have to enter with a needle from a separate device daily doses of oxygen into the implant to sustain the cells there. [16]A multidisciplinary group of researchers led by Prof. Amy Shen, developed a novel cryopreservation method that helps to protect pancreatic islets from ice damage, and facilitates real-time assessments of cell viability. The novel technique employs a droplet microfluidic device to encapsulate pancreatic islets in hydrogel made of alginate, a natural polymer extracted from seaweed. These capsules have a unique microstructure: a porous network and considerable amount of non-freezable water. Non-freezable bound water does not form ice due to the strong association between water molecules and the hydrogel networks. Hydrogel capsules with large amounts of non-freezable bound water protect the cells from the ice damage and reduce the need for cryoprotectants—special substances that minimise or prevent freezing damage and can be toxic in high concentrations. The hydrogel capsule allows small molecules, e.g. nutrients and islet secretions, to pass through the membrane easily, but prevents direct contact between implanted cells and host cells and so prevent an attack on transplants by the autoimmune response. [17] The use of a real-time single-islet oxygen sensor – a fluorescent oxygen-sensitive dye in hydrogel capsules allows to use a simple and cheap yet reliable individual-islet-based quality control of viability for the entire islet processing procedure prior to transplantation. Fluorescence indicates whether cells are consuming oxygen and, therefore, are alive and healthy. References [ edit]^ Lakey J, Burridge P, Shapiro A (2003). ""Technical aspects of islet preparation and transplantation"". Transpl Int. 16 (9): 613–632. doi: 10.1111/j.1432-2277.2003.tb00361.x. PMID 12928769.^ Close N, Hering B, Eggerman T (2005). ""Results from the inaugural year of the Collaborative Islet Transplant Registry"". Transplant Proc. 37 (2): 1305–1308. doi: 10.1016/j.transproceed.2004.12.117. PMID 15848704.^ Shapiro A, Lakey J, Paty B, Senior P, Bigam D, Ryan E (2005). ""Strategic opportunities in clinical islet transplantation"". Transplantation. 79 (10): 1304–1307. doi: 10.1097/01. TP.0000157300.53976.2A. PMID 15912095.^ Piemonti L, Pileggi A (2013). ""25 Years of the Ricordi Automated Method for Islet Isolation"" (PDF). Cell R4. 1 (1): 8–22.^ Lacy P, Kostianovsky M (1967). ""Method for the isolation of intact islets of Langerhans from the rat pancreas"". Diabetes. 16 (1): 35–39. doi: 10.2337/diab.16.1.35. PMID 5333500.^ Kemp C, Knight M, Scharp D, Lacy P, Ballinger W (1973). ""Transplantation of isolated pancreatic islets into the portal vein of diabetic rats"". Nature. 244 (5416): 447. doi: 10.1038/244447a0. PMID 4200461.^ Scharp D, Murphy J, Newton W, Ballinger W, Lacy P (1975). ""Transplantation of islets of Langerhans in diabetic rhesus monkeys"". Surgery. 77 (1): 100–105. PMID 122797.^ Lacy P (1978). ""Workshop on Pancreatic Islet Cell Transplantation in Diabetes sponsored by the National Institute of Arthritis, Metabolism, and Digestive Diseases and held at the National Institutes of Health in Bethesda, Maryland, on November 29 and 30, 1977"". Diabetes. 27 (4): 427–429. doi: 10.2337/diab.27.4.427. PMID 416985.^ Tzakis A, Ricordi C, Alejandro R, Zeng Y, Fung J, Todo S, Demetris A, Mintz D, Starzl T (1990). ""Pancreatic islet transplantation after upper abdominal exenteration and liver replacement"". Lancet. 336 (8712): 402–405. doi: 10.1016/0140-6736 (90)91946-8. PMC 2972674. PMID 1974944.^ Shapiro A, Lakey J, Ryan E, Korbutt G, Toth E, Warnock G, Kneteman N, Rajotte R (2000). ""Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen"". N Engl J Med. 343 (4): 230–238. doi: 10.1056/NEJM200007273430401. PMID 10911004.^ Robertson R (2004). ""Islet transplantation as a treatment for diabetes – a work in progress"". N Engl J Med. 350 (7): 694–705. doi: 10.1056/NEJMra032425. PMID 14960745.^ Hirshberg B, Rother K, Digon B, Lee J, Gaglia J, Hines K, Read E, Chang R, Wood B, Harlan D (2003). ""Benefits and risks of solitary islet transplantation for type 1 diabetes using steroid-sparing immunosuppression: the National Institutes of Health experience"". Diabetes Care. 26 (12): 3288–3295. doi: 10.2337/diacare.26.12.3288. PMID 14633816. Full text^ Ojo A, Held P, Port F, Wolfe R, Leichtman A, Young E, Arndorfer J, Christensen L, Merion R (2003). ""Chronic renal failure after transplantation of a nonrenal organ"". N Engl J Med. 349 (10): 931–940. doi: 10.1056/NEJMoa021744. PMID 12954741.^ ""Beta-o2 Technologies Company – About"". Beta-o2 Technologies Company. Beta-o2 Technologies Company. Retrieved Feb 20, 2015.^ ""Clinical trials"". Beta-O2 Technologies. Retrieved Feb 20, 2915. Check date values in: |access-date= ( help)^ ""Living with ßAir"". Beta-o2 Technologies Ltd. Beta-o2 Technologies Ltd. Retrieved Feb 20, 2015.^ Wanyu Chen, Zhiquan Shu, Dayong Gao, Amy Q. Shen (2015). Sensing and Sensibility: Single-Islet-based Quality Control Assay of Cryopreserved Pancreatic Islets with Functionalized Hydrogel Microcapsules. Advanced Healthcare Materials, doi: 10.1002/adhm.201500515External links [ edit]Chicago Diabetes Project: Global Collaboration for a Faster Cure NIH Clinical Islet Transplant Consortium (CIT)Collaborative Islet Transplant Registry (CITR)Uppsala University Hospital Updated Sept. 20, 2012VIDEO: Update on Islet Transplantation at the University of Wisconsin Dr. Luis Fernandez, November 2007. Clinical Islet Transplant Program – University of Alberta Diabetes Research Institute (DRI)Diabetes Clinical Trials Miami Islet Recipients [1]Mayo Clinic: Islet cell transplant: Emerging treatment for type 1 diabetes Islet Cell Transplant Program – UW Health Immune Tolerance Networkv t e Organ transplantation Types Allotransplantation ABOi Autotransplantation Xenotransplantation Organs and tissues Bone Bone marrow Brain Corneal Face Hand Head Heart Heart–lung Intestine Kidney Liver Living donor Lung Pancreas Islet cell Penis Skin Spleen Testicle Thymus Uterus Vagina Medical grafting Bone grafting Skin grafting Vascular grafting Organ donation Non-heart-beating donation Organ harvesting Organ trade Complications Graft-versus-host disease Post-transplant lymphoproliferative disorder Transplant rejection Transplant networks and government departments Balttransplant BC Transplant Society Eurotransplant Gift of Life Marrow Registry Human Tissue Authority Life Sharers National Marrow Donor Program NOD-Lb National Transplant Organization NHS Blood and Transplant Scandiatransplant Trillium Gift of Life Network United Network for Organ Sharing Advocacy organizations Anthony Nolan DKMS Donate Life America Halachic Organ Donor Society Kidney Foundation of Canada National Kidney Foundation ORGANIZEJoint societies American Society of Nephrology American Society of Transplantation Canadian Society of Transplantation Countries Organ transplantation in different countries Organ transplantation in China Organ transplantation in Israel Organ transplantation in Japan Organ theft in Kosovo Gurgaon kidney scandal People Heart Christiaan Barnard James D. Hardy Adrian Kantrowitz Richard Lower Norman Shumway Kidney J. Hartwell Harrison John P. Merrill Joseph Murray Michael Woodruff Liver Fikri Alican James D. Hardy Thomas Starzl Lung Fikri Alican Joel D. Cooper Vladimir Demikhov James D. Hardy Pancreas Richard C. Lillehei Penis André van der Merwe Other Alexis Carrel Jean-Michel Dubernard Donna Mansell Bruce Reitz List of organ transplant donors and recipients Related topics Biomedical tissue Edmonton protocol Eye bank Immunosuppressive drugs Lung allocation score Machine perfusion Total body irradiation Frankenstein's monsterv t e Surgery involving the endocrine system ( ICD-9-CM V3 06–07, ICD-10-PCS 0G)Pancreas Islet cell transplantationsee also digestive system procedures Pituitary Hypophysectomy Transsphenoidal surgery Combined rapid anterior pituitary evaluation panel Thyroid Thyroidectomy Parathyroidectomy Tests Radioactive iodine uptake test Sestamibi parathyroid scan TRH stimulation test Adrenal gland Adrenalectomy Tests Dexamethasone suppression test ACTH stimulation test Captopril suppression test Fluid deprivation test Pineal gland Pinealectomy Categories: Diabetes Transplantation medicine "


what type of shot do you get for whooping cough

s Side effects of the vaccine are usually mild and may include a fever, crankiness, headache, fatigue or soreness at the site of the injection. Booster shots Adolescents. Because immunity from the pertussis vaccine tends to wane by age 11, doctors recommend a booster shot at that age to protect against whooping cough (pertussis), diphtheria and tetanus. Adults. Some varieties of the every-10-year tetanus and diphtheria vaccine also include protection against whooping cough (pertussis). This vaccine will also reduce the risk of your transmitting whooping cough to infants. Pregnant women. Health experts now recommend that pregnant women receive the pertussis vaccine between 27 and 36 weeks of gestation.

Overview

"Print Overview

Whooping cough (pertussis) is a highly contagious respiratory tract infection. In many people, it's marked by a severe hacking cough followed by a high-pitched intake of breath that sounds like ""whoop. ""Before the vaccine was developed, whooping cough was considered a childhood disease.

Now whooping cough primarily affects children too young to have completed the full course of vaccinations and teenagers and adults whose immunity has faded. Deaths associated with whooping cough are rare but most commonly occur in infants. That's why it's so important for pregnant women — and other people who will have close contact with an infant — to be vaccinated against whooping cough. Symptoms Once you become infected with whooping cough, it takes about seven to 10 days for signs and symptoms to appear, though it can sometimes take longer. They're usually mild at first and resemble those of a common cold: Runny nose Nasal congestion Red, watery eyes Fever Cough After a week or two, signs and symptoms worsen. Thick mucus accumulates inside your airways, causing uncontrollable coughing. Severe and prolonged coughing attacks may: Provoke vomiting Result in a red or blue face Cause extreme fatigue End with a high-pitched ""whoop"" sound during the next breath of air However, many people don't develop the characteristic whoop. Sometimes, a persistent hacking cough is the only sign that an adolescent or adult has whooping cough. Infants may not cough at all. Instead, they may struggle to breathe, or they may even temporarily stop breathing. When to see a doctor Call your doctor if prolonged coughing spells cause you or your child to: Vomit Turn red or blue Seem to be struggling to breathe or have noticeable pauses in breathing Inhale with a whooping sound Request an Appointment at Mayo Clin

ic Causes Whooping cough is caused by a type of bacteria called Bordetella pertussis. When an infected person coughs or sneezes, tiny germ-laden droplets are sprayed into the air and breathed into the lungs of anyone who happens to be nearby. Risk factors The whooping cough vaccine you receive as a child eventually wears off.

This leaves most teenagers and adults susceptible to the infection during an outbreak — and there continue to be regular outbreaks. Infants who are younger than age 12 months who are unvaccinated or haven't received the full set of recommended vaccines have the highest risk for severe complications and death. Complications Teens and adults often recover from whooping cough with no problems. When complications occur, they tend to be side effects of the strenuous coughing, such as: Bruised or cracked ribs Abdominal hernias Broken blood vessels in the skin or the whites of your eyes Infants In infants — especially those under 6 months of age — complications from whooping cough are more severe and may include: Pneumonia Slowed or stopped breathing Dehydration or weight loss due to feeding difficulties Seizures Brain damage Because infants and toddlers are at greatest risk of complications from whooping cough, they're more likely to need treatment in a hospital. Complications can be life-threatening for infants younger than 6 months old. Prevention The best way to prevent whooping cough is with the pertussis vaccine, which doctors often give in combination with vaccines against two other serious diseases — diphtheria and tetanus. Doctors recommend beginning vaccination during infancy. The vaccine consists of a series of five injections, typically given to children at these ages:2 months4 months6 months15 to 18 months4 to 6 years Vaccine side effect

This may also give some protection to the infant during the first few months of life. Preventive medications If you've been exposed to someone who has whooping cough, your doctor may recommend antibiotics to protect against infection if you: Are a health care provider Are pregnant Are younger than age 12 months Have a health condition that could put you at risk of severe illness or complications, such as a weakened immune system or asthma Live with someone who has whooping cough Live with someone who is at high risk of developing severe illness or complications from a whooping cough infection By Mayo Clinic Staff Request an Appointment at Mayo Clinic Diagnosis & treatment Feb. 10, 2018Print Share on: Facebook Twitter References Related Whooping cough Childhood vaccines Childhood vaccines Vital Vaccinations Vaccination schedule Symptom Checker Vaccines for adults Fatigue Runny nose Nausea and vomiting Cough Nasal congestion Red eye Whooping cough Symptoms & causes Diagnosis & treatment Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship Policy Opportunities Ad Choices Mayo Clinic Marketplace Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. FREE TRIAL – Mayo Clinic Health Letter Stop Osteoporosis in Its Tracks Improve Your Hearing and Balance Best Treatment Strategies for Arthritis The Mayo Clinic Diet Online CON-20378955Patient Care & Health Information Diseases & Conditions Whooping cough "


what is net gain

ch Net gain may refer to: Net gain (telecommunications), the overall gain of a transmission circuit. Net (economics)Net profit Net income

Net gain

Net gain From Wikipedia, the free encyclopedianavigation sear

This disambiguation page lists articles associated with the title Net gain. If an internal link led you here, you may wish to change the link to point directly to the intended article. Categories: Disambiguation pages


what is the dare font

Dare font Dare font is decorative font which is designed by CJ Cook. This font is labeled as Brush font. Dare font family has 1 variant.

Dare font

author CJ Cook http://facebook.com/cjwcooklicense Free for personal usetagsdecorative, brush, dareauthor note Font I made that is similar to the old DARE program. If you wanna use it for personal use be my guest, if you want to use it for commercial use contact me. b0bafett77@yahoo.com CJ Cook... read more. Quick preview: Dare font variants (1 fonts)DARE, Regulardemo add ttf @font-face Dare Fontby CJ Cook Brush font, decorative, 1 variant Format: True Type Font License: Free


how many pounds of fat can you lose in a week

Well, it’s certainly possible to lose more than two pounds per week, but it’s critically important to understand that there’s a world of difference between rapid weight loss and permanent fat loss.

The 2 Pounds Per Week Rule and How to Burn Fat Faster Published by Fit Watch Tom Venuto is a natural bodybuilder, certified strength and conditioning specialist (CSCS) and a certified personal trainer (CPT). I’ve learned so much from Tom through his Burn the Fat, Feed the Muscle Program. No hype, no gimmicks — Tom shoots straight from the hip, and tells you the truth about fat loss. Why do you always hear that 2 pounds per week is the maximum amount of fat you should safely lose? If you train really hard while watching calories closely shouldn’t you be able to lose more fat without losing muscle or damaging your health? What if you want to lose fat faster? How do you explain the fast weight losses on The Biggest Loser? These are all good questions that I’ve been asked many times. With the diet marketplace being flooded every day with rapid weight loss claims, these questions desperately need and deserve some honest answers. Want to know where that 2 pounds per week rule comes from and what it really takes to burn more than 2 pounds of fat per week? Read on. Why Only 2 Pounds Per Week? The truth is, two pounds is not the maximum amount you can safely lose in a week. That’s only a general recommendation and a good benchmark for setting weekly goals. It’s also sensible and realistic because it’s based on average or typical results. The actual amount of fat you can lose depends on many factors. For example, weight losses tend to be relative to body si

ze. The more body fat you carry, the more likely you’ll be able to safely lose more than two pounds per week. Therefore, we could individualize our weekly guideline a bit by recommending a goal of 1-2 lbs of fat loss per week or up to 1% of your total weight. If you weighed 300 lbs, that would be 3 lbs per week. Body Weight Vs Body Composition Weight loss is somewhat meaningless unless you also talk about body composition; the fat to muscle ratio, as well as water weight.

Ask any wrestler about fast weight loss and he’ll tell you things like, “I cut 10 lbs overnight to make a weight class. It was easy – I just sweated it off.”You’ve also probably seen people that went on some extreme induction program or a lemon juice and water fast for the first week and dropped an enormous amount of weight. But once again, you can bet that a lot of that weight was water and lean tissue and in both cases, you can bet that those people put the weight right back on. The main potential advantage of any type of induction period for rapid weight loss in the first week is that a large drop on the scale is a motivational boost for many people (even if it is mostly water weight). Why do you hear so many diet and fitness professionals insist on 2 lbs a week max? Where does that number come from? Well, aside from the fact that it’s a recommendation in government health guidelines and in position statements of most nutrition and exercise organizations, it’s just math. The math is based on what’s practical given the number of calories an average person burns in a day and how much food someone can reasonably cut in a day. How Do You Lose More Than 2 Pounds Per Week? Can you lose more than 2 lbs of pure fat in a week? Yes, although it’s easier in the beginning. It gets harder as your diet progresses. How do you do it? My rule is, extraordinary results require extraordinary efforts. An extraordinary effort means a particularly strict diet, as well as burning more calories through training because you can only cut your calories so far from food before you’re starving and suffering from severe hunger.

Simply put, you need a bigger calorie deficit. If you have a 2500 calorie daily maintenance level, and you want to drop 3 lbs of fat per week withe diet alone, you’d need a huge daily deficit of 1500 calories, which would equate to eating 1000 calories per day.

You would lose weight rapidly for as long as you could maintain that deficit (although it would slow down over time). Most people aren’t going to last long on so little food and they often end with a period of binge eating. It’s not practical (or fun) to cut calories so much and in some cases it could be unhealthy. The other alternative is to train for hours and hours a day, literally. People ask me all the time, “Tom, how is it possible for the Biggest Loser contestants to lose so much weight? Well first of all they’re not measuring body fat, only body weight. Then you have the high starting body weights and the large water weight loss in the beginning. After that, just do the math – they’re training hours a day so they’re creating a huge calorie deficit. But without that team of trainers, dieticians, teammates, a national audience and all that prize money, do you think they’d be motivated and accountable enough to do anywhere near that amount and intensity of exercise in the real world? Would it even be possible if they had a job and family? Not likely, is it? It’s not practical to do that much exercise, and it’s not practical to cut your calories below a 1000 a day and remain compliant. If you manage to achieve the latter, it’s very difficult not to rebound and regain the weight afterwards for a variety of physiological and psychological reasons. For Fast Fat Loss: Less Food Or Harder Training? Trainers are becoming more inventive these days in coming up with high intensity workouts that burn a large amount of calories and really give the metabolism a boost. This can help speed up the fat loss within a given amount of time. But as you begin to utilize higher intensity workouts, you have to start being on guard for overtraining or overuse injuries. That’s why strict nutrition with an aggressive calorie deficit is going to have to be a major part of any fast fat loss strategy. Unfortunately, very low calorie dieting has its own risks in the way of lean tissue loss, slower metabolism, extreme hunger, and greater chance of weight re-gain. My approach to long term weight control is to lose weight slowly and patiently and follow a nutrition plan that is well balanced between lean protein, healthy fats and natural carbs and doesn’t demonize any entire food group. To lose fat, you simply create a caloric deficit by burning more and eating less (keeping the nutrient density of those calories as high as possible, of course). But to achieve the extraordinary goals such as photo-shoot-ready, super-low body fat or simply faster than average fat loss, while minimizing the risks, I often turn to a stricter cyclical low carb diet for brief “peaking” programs. I explain this method in chapter 12 of my e-book Burn The Fat, Feed The Muscle (it’s my “phase III” or “competition” diet). The cyclical aspect of the diet means that after three to six days of an aggressive calorie deficit and strict diet, you take a high calorie / high carb day to re-feed the body and re-stimulate the metabolism. Essentially, this helps reduce the starvation signals your body is receiving. It’s also a psychological break from the deprivation which helps improve compliance and prevent relapse. The higher protein intake can help prevent lean tissue loss and curb the hunger. A high protein diet also helps by ramping up dietary thermogenesis. A high intake of greens, fibrous vegetables and low calorie fruits can help tip the energy balance equation in your favor as fibrous veggies are very low in calorie density and some of the calories in the fiber are not metabolizable. Healthy fats are added in adequate quantities, while the calorie-dense simple sugars and starchy carbs are kept to a minimum except on refeed days and after (or around) intense workouts. There’s No Magic, Just Math In my experience, a high protein, reduced carb approach in conjunction with weights and cardio can help maximize fat loss – both in terms of increasing speed of fat loss and particularly for getting rid of the last of the stubborn fat. It helps with appetite control too. But always bear in mind that the faster fat loss occurs primarily as a result of the larger calorie deficit (which is easily achieved with sugars and starches minimized), not some type of “low carb magic.” If your diet were high in natural carbs but you were able to diligently maintain the same large calorie deficit, the results would be similar. I’m seeing more and more advertisements that not only promise rapid weight loss, but go so far as saying that you’re doing it wrong if you’re losing “only” two pounds per week. “Why settle” for slow weight loss, they insist.

It’s also vital to know that there’s no magic in faster fat loss, just math. All the new-fangled dietary manipulations and high intensity training programs that really do help increase the speed of fat loss all come full circle to the calorie balance equation in the end, even if they claim their method works for other reasons and they don’t mention calories burned or consumed at all. Beware of The Quick Fix Faster fat loss IS possible. My question is, are you willing to tolerate the hunger, low calories and high intensity exercise for that kind of deficit? Do you have the work ethic? Do you have the supreme level of dietary restraint necessary to stop yourself from bingeing and putting the weight right back on when that aggressive diet is over? Or would you rather do it in a more moderate way where you’re not killing yourself, but instead are making slow and steady lifestyle changes and taking off 1-2 lbs of pure fat per week, while keeping all your hard-earned muscle? Remember, 1-2 pounds per week is 50-100 pounds in a year. Is that really so slow or is that an astounding transformation? You don’t gain 50-100 pounds over night, so why should anyone expect to take it off overnight? Personally, I think short-term thinking and the pursuit of quick fixes are the worst diseases of our generation. If you want to be one of those “results not typical” fat loss transformations, it can be done and it may be a perfectly appropriate short-term goal for the savvy and sophisticated fitness enthusiast. It’s your call. But when you set your goals, it might be wise to remember that old fable of the tortoise and the hare, and buyer beware if you go shopping for a fast weight loss program in today’s shady marketplace. Train hard and expect success,Tom Venuto Fat Loss Coach www.burnthefat.com About the Author: Tom Venuto is a natural bodybuilder, certified strength and conditioning specialist (CSCS) and a certified personal trainer (CPT). Tom is the creator of the “ Burn the Fat, Feed the Muscle Program ,” which teaches you how to get lean without drugs or supplements using methods of the world’s best bodybuilders and fitness models. Learn how to get rid of stubborn fat and increase your metabolism by visiting: www.burnthefat.com


how big does a pomsky get

y Average Pomsky Size On average, you can expect a full grown 50/50 pomsky to be about: A full grown adult pomsky is approximately 12 to 17 inches long, 10 to 15 inches tall (from floor to shoulder blade) and weighs about 20 to 30 pounds10 to 15 inches tall (from floor to shoulder blade)

How Big Do Pomskies Get?

How Big Do Pomskies Get?5 Apr, 2016 in Pomsky Facts tagged Pomsky facts by Pomsky Owners Association How Big Do Pomskies Get? Full grown adult pomskies range in size depending on a couple of factors: The type of Pomeranian husky mix Parents of the pomsk

12 to 17 inches long (from chest to rear)20 to 30 pounds in weight There is no guarantee that a pomsky will be EXACTLY these dimensions, but typically you can expect your 50/50 pomsky to be about this size. How Fast Do Pomskies Grow? A pomsky typically reaches its full grown size within a year. By six months the pomsky is more than half way done growing; by a year you can expect your pomsky to be just about fully grown. How to Estimate The Size Of Your Pomsky The size of a full grown pomsky depends heavily on the parent and the type of cross breed. The breeder will not be able to guarantee size, but they will be able to provide a rough estimate of a litter’s size based on the parent’s size and the pomskies growth within the first couple weeks after being born. Free Download: 40+ Reputable Pomsky Breeders List Parents Of The Pomsky The average female Siberian husky is about 20 to 22 inches tall and weighs 35 to 50 pounds, whereas the average male Pomeranian is 8 to 11 inches tall and weighs 3 to 7 pounds. If a pomsky is bred from a smaller female Siberian husky and smaller Pomeranian, you can expect the size of your pomsky to be smaller than average. Pomeranian Husky Mix A 50/50 cross breed, meaning the pomsky is 50% husky and 50% Pomeranian, will be larger than the 25/75 because it is 50% husky (which is much larger than the Pomeranian). A 25/75 cross breed, meaning the pomsky is 25% husky and 75% Pomeranian, is smaller than the average 50/50 pomsky and will be closer in size to the Pomeranian. A 75/25 cross breed, meaning the pomsky is 25% Pomeranian and 75% husky is only slightly smaller than the average female husky and will be the largest of all the Pomeranian husky mix variations. Remember to consult your pomsky breeder for more information about estimating your pomsky’s size.


dennis franz where does he live

ary Dennis Franz is 73 years old and was born on 10/28/1944. Currently, he lives in Santa Barbara, CA; and previously lived in los angeles, CA and coeur d alene, ID . Sometimes Dennis goes by various nicknames including Dennis Franz Schalachta, Dennis F Schlachta, Franz Schlachta Dennis, Franz S Dennis, Denn S Franz, Dennis Franz Schlachta, Dennis F Franz. His political affiliation is currently a registered Republican Party.

Dennis Franz, 73

"About & Contact Info Photos & Social Posts Reviews & Ratings Criminal & Court Records Friends & Family View Photos Dennis Franz, 73Santa Barbara, CAWork: Info Pending... School: Info Pending... AKA: Dennis Franz Schalachta, Dennis F Schlachta, Franz Schlachta Dennis, Franz S Dennis, Denn S Franz, Dennis Franz Schlachta, Dennis F Franz Edit Free Photos Share Message Reputation Score0.00 ( 1 Review )Negative Rate Me Positive Write a Review | Ask others to Rate BAD POOR FAIR GOODDennis Franz is 73 years old and was born on 10/28/1944. Currently, he lives in Santa Barbara, CA; and previously lived in los angeles, CA and coeur d alene, ID. Read More View Full Background Details Claim & Manage My Background Report Learn more Learn more Contact Information- View Full Details Phone: View Phone Number Email: View Email Address Address: 24*** **** Ave Santa Barbara, CA 93108About Dennis Franz- Edit Info Birthday: 10/28/1944Income: Info Pending... Current Net Worth: Info Pending... Political Affiliation: Republican Party Ethnicity: Info Pending... Relationship: Info Pending... Kids: Info Pending... Religion: Info Pending... Where does this information come from? We gather information from public sources to create complete and current Background Reports & Reputation Scores for everyone. We believe it's important for you to know what's available online, how it affects your Reputation Score & help you correct or remove what's wrong to improve your reputation & life. About & Contact Information Dennis's Story - Edit My Story Dennis, this is where you can tell everyone about the things you're proud of. If you are not Dennis, share your positive experiences with them. Summary - Edit Summ

Contact Information This section includes information on Addresses, Phone Numbers, and Email Addresses Recent Address24 *** **** Ave Santa Barbara, CAView Address Past Address23 *** **** Hl Los Angeles , CAView Address Past Address P *** **** 5370Santa Barbara , CAView Address Past Address38 *** **** Rd Coeur D Alene , IDView Address Email Address****@yahoo.com View Email Email Address****@ca.rr.com View Email Email Address****@aol.com View Email Dennis may have hidden Social Profiles & Photos - Check Full Background Report to see Dennis's social media activity. This may contain online profiles, dating websites, forgotten social media accounts, and other potentially embarrassing profiles. This may also contain additional contact information, giving you more ways to get in touch. View Full Phone, Email & Address Details Work History [ Edit Work]Dennis may have Work information - Check Full Background Report to see possible job history including what current and previous jobs, companies they may have been employed at, job titles, duration of employment, and a list of their co-workers. View Full Background Details School History [ Edit Schools]Dennis may have Education Information - Check Full Background Report to see possible education history including where and when they attending high school and college, and a complete list of their high school class list. View Full Background Details Properties [ Edit Properties]This section may reveal information on property that Dennis owns including purchase price of his house, other real estate, and automobiles registered to him. Current Home Value: Info Pending... Home Purchase Price: Info Pending... Automobile Year: 2004Make: FORDModel: EXPEDITIONView Full Background Details Corporate Affiliations Dennis may have Corporate Affiliations - Check Full Background Report to see a complete list of known corporate affiliations. This may contain information such as company name, job title, address, and time period of service. View Full Background Details Licenses and Permits Dennis may have Licenses & Permits - Check Full Background Report to see weapons permits, Federal Aviation Administration pilot licenses and Drug Enforcement Administration licenses for prescribing controlled pharmaceuticals. If applicable, you will also see Dennis's license number and expiration date. View Full Background Details Photos & Social Posts Photos View Photos Social Posts Reviews & Ratings Dennis Franz's Reputation Score:4.50/5 ( 1 Review )Rate: Dennis Improve my Rating | Ask others to Rate | Write a Review Ranking: Compared to U. S. Population BAD POOR FAIR GOODMy Life Team Personal Review We are thrilled to introduce your personal review section. We assume the best of everyone we first meet, and agree with Hemingway when he said ""The best way to find out if you can trust somebody is to trust them. ""PLEASE ASK OTHERS TO REVIEW YOU - it is important. We expect your reviews to be a positive reflection of who you are, helping you to build a great reputation that friends, employers, clients, dates, and everyone will see. It is how people assess you, just like a business on Yelp, so it is important that you look good to the world. Reply Criminal & Court Records Court, Arrest or Criminal Records Dennis may have Court, Arrest or Criminal Records - Check Full Background Report to see possible arrest or conviction records we have found on Dennis. This may include any DUIs, traffic tickets and outstanding warrants. When applicable, we may show where the crime occurred and provide details about the offense. View Full Background Details Lawsuits, Liens or Bankruptcies Dennis may have Lawsuits, Liens or Bankruptcies - Check Full Background Report to see local, state and federal court documents, sensitive legal information and any litigation that Dennis may have been involved in. We'll reveal arrest details like case numbers, offense descriptions, and booking dates, where available. View Full Background Details Sex Offender Status Dennis may have Sexual Offenses - Check Full Background Report to see a complete list of any and all sex offenses Dennis may have been convicted of and his current sex offender status if applicable. View Full Background Details Family & Friends Relatives/Associates Dennis may have a record of Relatives/Associates - Check Full Background Report to see possible family members, friends, co-workers, and associates found from multiple government records, social and public sources. View Full Background Details Classmates Dennis may have a record of associated Classmates - Check Full Background Report to see possible who they are and full classlists found from school records and public sources. View Full Background Details Neighborhood Information| Information based on current address Age Education Level Household Income Estimated Home Values Top Buying Habits Top Interests & Hobbies Find Another Dennis Franzdf Dennis Franz, 77Auburndale, FLdf Dennis Franz, 70Pembroke Pines, FLdf Dennis Franz, 45Winter Springs, FLdf Dennis Franz, 71Oakbrook Terrace, ILdf Dennis Franz, 49Oakbrook Terrace, ILdf Dennis Franz, 49Westmont, ILView More "


how long do i bake squash seeds

(If you do not pierce the squash it may EXPLODE in the oven!) Once it has cooled, you can cut it in half, scoop out the seeds and either cut the skin off or scoop out the flesh. This is a great method to use if the squash is going to be pureed for a side dish or soup. Option 4. Roasting squash: Once you have cut the squash in half and scooped out the seeds you can roast it. Preheat the oven to 400F and drizzle the squash halves with some olive oil, salt and pepper. Put them cut-side down on a baking sheet, and roast for about 40 minutes.

How to: Squash

How to: Squashposted in Food, Vegetables and Beans by Jessica Howardprevious | next Can you spot the buttercup squash? If not, read on!As autumn arrives, grocery stores and markets fill up with winter squash in all shapes and sizes. Acorn, butternut, buttercup, spaghetti … which one is which? And what do you do with them? This post will introduce you to some of the more popular members of the gourd family. Even if you don’t end up cooking with them, you can use them as seasonal decorations!How to Choose Squash Winter squash have tough, inedible skins. When buying winter squash, look for ones that are heavy and have smooth, un-dented skins with the stems still on. These are indications that the squash was harvested when ripe and will have more flavor. Winter squash contain lots of healthy nutrients, like Vitamin A, Vitamin C, potassium and fiber. Whole squash can be kept for up to a month, unrefrigerated, in a cool dry location. Preparing Winter Squash Most squash varieties can be baked, boiled, steamed and sautéed, but they each have different tastes and textures. Particular cooking techniques are better suited to some than others – don’t try making butternut squash soup with spaghetti squash!To prepare squash, start by washing it off and drying it. The next step will depend on how you want to use the squash and whether you have a good, sharp knife. Option 1. Cut the Squash Before Cooking: Peeling squash is not easy, which is why some people roast squash unpeeled. You can peel the squash with a vegetable peeler (as shown it this video) or with a knife. Then you can cut it in half, scoop out the seeds and cut the flesh into whatever size pieces you need. Or, you can simply cook the two peeled/scooped-out halves in the oven (at 400F for about 40 minutes) or the microwave (calculating two minutes of cooking time per pound of squash). Option 2. Partially Cook the Squash Before Cutting: If the squash is too hard to cut, try microwaving it for a minute or two, or boiling it for five minutes. You’ll have to let it cool and then try to cut it. Option 3. Cut the Squash After Cooking: Another way to avoid cutting a raw squash is to bake it whole. Pierce the squash in several places (using a fork or sharp knife) to let air escape, then bake it at 400F for about an hour.

Kathy roasted all the squash she photographed, shown below cut-side down……then turned each piece over to check that it was done. Now, let’s find out who’s who in the squash family!Butternut Squash (shown below)Butternut squash is one of the most popular varieties because of its sweet, rich taste and beautiful orange color. These creamy-skinned squashes have a bulb-shaped end that contains the seeds. Butternut squash can be served pureed with apples or as the made into butternut squash soup. Here’s a video that demonstrates maple-glazed butternut squash, a delicious and simple side-dish that calls for a quarter cup of rum. You can also use plain baked butternut squash as a side dish, salad or pasta topping. Buttercup Squash (shown below)Buttercup squashes are round and flat in shape and often have dark green skins. Although their flavor is similar to that of butternut squash, they’re not as sweet and they have a drier texture. They work well in many of the same recipes as butternut squash. Here’s a recipe for Brandy-Laced Squash Soup with Cinnamon and Bay Leaves. Spaghetti Squash (shown below)These oval-shaped squash produce stringy flesh that can actually substitute for pasta. (It looks like pasta but tastes like watery summer squash!) The flavor is mild, so you can serve it with a pasta sauce or parmesan cheese, or even just a little olive oil, salt and pepper. Kathy explains how to cook and serve basic spaghetti squash, or try this Mediterranean version. Acorn Squash (shown below)Shaped like (you guessed it!) acorns, and typically dark green on the outside, this type of squash tastes great baked. Its nutty flesh is a bit drier than that of other squash varieties. You’ll often see recipes for stuffed acorn squash, because an acorn squash half makes an attractive, edible bowl. Delicata Squash (shown below)These long, cylindrical squash are also known as sweet potato squash because their creamy flesh resembles that of a sweet potato. They can be used in many recipes that call for butternut or buttercup squashes or sweet potato. Here’s a recipe for Delicata Squash and Gruyere Dip. Pumpkin (shown below)While these bright orange globes are the most sought after of the squash family, they get carved for Halloween more often than eaten. The size of pumpkins makes them a bit difficult to handle in the kitchen, which is why there’s a marvelous invention called canned pumpkin. Kathy makes use of pumpkin puree in her Pumpkin Soup Without the Fuss and in her Pumpkin Pie for Beginners. Summer Squash (shown below)Yellow summer squash (shown above) and green zucchini (shown below) are also part of the gourd family. We have already covered how to prepare zucchini and yellow-skinned summer squash can be prepared in many of the same ways. Here’s a recipe specifically for summer squash. If you are new to startcooking, or are a regular visitor here, please consider subscribing for free.subscribe |11 Comments Kathy Maister said: After I photographed all this squash, I roasted the butternut, buttercup, delicata and acorn squash. Once they all cooled off I scraped out all of the squash from their skins and popped the squash in my Cuisinart. Within just a few minutes I had a smooth puree of a squash blend. I could have added some maple syrup or honey. Instead I added some agave nectar and a sprinkle of salt. The squash blend tasted out of this world!I froze most of it in quart size freezer bags. If you lay them flat and squeeze out all the air, they take up very little space in the freezer. Frozen Mushroom Gravy, Chicken Gravy, Sweet Potatoes and Squash Blend Jennifer said: Great post Kathy! Squash is a great, naturally creamy, low-fat ingredient for soups, pasta, and risottos. Janette Brewster said: Great and easy presentation kathy!! Any suggestions how to bake the seeds without them being too dry?? HAPPY THANKSGIVING!! !mariana villasenor said: I baked the seeds once putting the seeds into water and salt for two minutes, then i took out the water, they were baked in ten minutes and never got dry.startcooking said: Thanks for the tip Mariana! I have never baked squash seeds, so I appreciate the comment. Bobby Godwin said: I love fried yellow squash. My problem is, sometimes they turn out great. They are nice and crispy. Other times, they are greasy and limp. I don’t know what I am doing wrong, unless it has something to do with the heat. I usually use a medium heat on an electric stove, but I still seem to be inconsistent. Any ideas what I am doing wrong?startcooking said: Hi Bobby, Are you preheating your pan? Try putting the oil in the pan and turning the stove to medium ( or medium high). Let the oil heat until it shimmers, which could take at least 1 minute. Add one slice of squash to the pan. If it does not sizzle immediately, then the oil is not hot enough, which in turn will yield soggy squash. Good luck and be sure to let me know if this works! Cheers, Kathy Bobby Godwin said: Yes, I do preheat the pan and oil. I cook until they are golden brown.startcooking said: Hmmm. Perhaps it is just that some squash is more watery than others. When I make Eggplant Parmesan, I slice the eggplant and then salt it to sweat out some of the moisture. You could give that a try and see if you get more consistent results. K. Bobby Godwin said: Thanks. I’ll give this a try. Love To Cook said: Bobby, I find that my yellow squash cooks crispest in small batches. If your quantity of squash is varried, this may account for the different results.


what is a parking brake

What is the Purpose of a Parking Brake Posted on August 6, 2013 by Dave Johnson The parking brake or also known as the emergency brake mechanism on your car is a device that when it is applied it extends the rear shoes or contract the rear pads and holds the weight of the vehicle by the rear brakes.

What is the Purpose of a Parking Brake

It is important to use the parking brake every time the vehicle is parked and left unoccupied. The parking brake can be found to the left of your brake pedal on the floorboard or it can also be located near the center consul or shifter, depending on the make and model of your car. Often time the parking brake is used while parking on an inclined surface. The parking brake helps keep the car in place and not move. ADJUSTING THE PARKING BRAKEJust as regular brakes need adjusting after a certain time, the parking brake does also. The most common problem with parking brakes on an automatic transmission is that the parking brake rarely gets used causing the brake cables to corrode. If you notice that your parking brake is not working as it should then the components of your parking brake may need to be cleaned to rid itself of any corrosion and dirt from not getting used. If this is the case you should take your car to your mechanic to get it checked. Vehicles that have a manual transmission use their parking brake a lot more. The parking brake should be used each time your car is off and unoccupied for your safety and so your car does not roll away. DRIVING WITH YOUR PARKING BRAKE ONDriving with the parking brake on can present a potential problem for the brake system. If you do happen to drive with the parking brake on you can cause wear to the linings of the vehicle’s main brakes. The moving wheel causes friction when the brake is applied, wearing away the brake pad or disc. There is also a possibility that the engine’s temperature will rise above safe levels because of the added friction that is additional when such pressure is there. If this does happen a warning light that indicates a high engine temperature may alert you and you should shut off your vehicle immediately. If this is not addressed it can result in radiator damage, cracked head gasket, or many other things. You might notice a rubber smell that is given off from the braking system being pressed. This is often the most noticeable sign your car will give off for you to know that something is not right. MAINTAINING YOUR PARKING BRAKEYour parking brake is an important safety feature on your car, which is why keeping it properly maintained is significant. If your parking brake does not get used as much as it should then you might experience problems with it sticking. You might also find that if you leave your car sit for an extended amount of time with the parking brake on it can get stuck. Using your parking brake on a regular basis will help make sure this does not happen. There is a cable that connects to the parking brake pedal or lever and this sometimes can get rusted, causing the other cables that make the parking brake to work to bind up and freeze. Parking brakes are an important safety feature on your car and it is smart to get in the habit of using it on a regular basis. Share this: Facebook Google Twitter‹ Make sure your vehicle is safe by checking the lights Save Money on Summertime General Vehicle Repair ›Posted in Auto Repair, Brake Repair, General Car Maintenance, Parking Brake Tagged with: Minnesota, Plymouth